leukocyte elastase การใช้

• Elafin, the skin-derived elastase inhibitor, has been shown to be a potent and specific inhibitor of both the porcine homolog of ELA1 and human leukocyte elastase in vitro.
• Other pharmaceutical and non-pharmacological treatments that have been tried, but shown no scientific efficacy include leukocyte elastase protease inhibitors, the EIPH Patch, hyperbaric oxygen therapy, pentoxyfylline, guanabenz, clonidine, snake venom, and enalapril.
• It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G . Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity.